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Want to see the science behind each ingredient? Read the complete formula breakdown — 11 ingredients, 23 clinical studies, every PubMed link.
Read Ingredient Science →Your Heart Did Not Fall Sick First.
Your Liver and Kidneys Did.
And Nobody Told You.
The AHA published this in 2024. Charaka wrote it 2,400 years ago. Most people still treat only the heart — and wonder why nothing works.
Read These 6 Signs First.
If even one of these is true — what you read on this page directly explains why.
2,400 Years Ago, One Indian Physician Described Your Heart Attack Risk Better Than Your Modern Blood Test Does
Charaka, the father of Ayurvedic medicine, listed the heart (Hridaya), liver (Yakrit) and kidneys (Vrikka) together — not as three separate organs, but as one unified group called Koshthanga. He said blood is made in the liver. The kidneys keep that blood clean. The heart pumps that clean blood everywhere. Break one link — and all three suffer.
No MRI machines. No blood tests. Yet in 2024, the world's leading heart journal published the same framework and named it the Cardio-Renal-Hepatic Axis.
Charaka Samhita — ~400 BCE
Hridaya, Yakrit and Vrikka are Koshthanga — one interconnected system. Blood forms in the liver. The kidneys filter it. The heart distributes it. A diseased liver starves the heart. A weak kidney poisons the blood the heart must pump.
Cha. Sa. Sharira Sthana 7/10
Circulation Research — 2024 CE
"The liver and heart are closely interconnected organs, and their bidirectional interaction plays a central role in cardiometabolic disease." They formally named this the Cardio-Renal-Hepatic Axis.
American Heart Association · Circulation Research · 2024 ↗ Read Study
You Gave Up Ghee. You Walk Every Morning. You Take Your Medicines. So Why Is Your Cholesterol Still High?
The answer is not your willpower or your diet. It is your liver.
When the liver is under stress — even silently — it begins manufacturing dangerous cholesterol internally through a process called de novo lipogenesis. This happens completely independent of what you eat. Ayurveda documented this mechanism 1,300 years ago.
"Ranjaka Pitta lives in the Yakrit (liver). Its job is to maintain the quality of Meda Dhatu — body fat and lipids. When Ranjaka Pitta is disturbed, the liver produces toxic, atherogenic fat called Abaddha Meda — even on a perfect diet."
Ashtanga Hridaya Sutra Sthana 12/13 — ~700 CEAshtanga Hridaya — 700 CE
When Ranjaka Pitta in the Yakrit is disturbed — Yakrit Dushti — the liver begins producing Abaddha Meda (toxic free-circulating fat). This enters the Raktavaha Srotas (arteries) and causes Dhamani Pratichaya — what we now call atherosclerosis. Diet alone cannot stop this process.
Ashtanga Hridaya Sutra Sthana 12/13
Frontiers in Medicine — 2024
In fatty liver disease, the liver overproduces VLDL and small dense LDL through de novo lipogenesis — completely independent of dietary fat intake. Research confirmed: "Dietary cholesterol alone cannot explain dyslipidemia in fatty liver. Hepatic fat synthesis must be addressed." Even on a zero-fat diet, a damaged liver manufactures dangerous cholesterol internally.
Frontiers in Medicine 2024 · NCBI Lipid Metabolism Review 2018 ↗ Read Study
Charaka Called It "Ama."
Scientists Call It "Oxidized LDL."
Both Mean the Same Thing —
Metabolic Poison Clogging Your Arteries.
Ama means unprocessed metabolic waste. When your liver cannot fully process fat, and your kidneys cannot fully filter blood — this waste builds up. It mixes with your fat tissue. It enters your arteries. It causes blockages.
Charaka said Ama is the real cause of heart disease — not cholesterol itself, but toxic, unprocessed cholesterol that the liver failed to transform. In 2016, the European Uremic Toxin Work Group identified the same molecules: indoxyl sulfate, TMAO, carbamylated LDL. Same poison. Different name. 2,400 years later.
Charaka Samhita — ~400 BCE
Ama forms when Agni (metabolic fire — primarily in the liver) is weak. Sticky, heavy, toxic — it mixes with Meda Dhatu (fat), enters Raktavaha Srotas (arteries) and causes Dhamani Pratichaya (arterial blockage). Ama builds faster when liver and kidney function are both poor. Treating the heart while ignoring Ama is like mopping the floor while the tap is still running.
Charaka Samhita Chikitsa Sthana 26
Frontiers in CV Medicine — 2025
Uremic toxins — produced when kidneys fail to filter — chemically modify LDL through carbamylation and oxidation, making it 3–5× more atherogenic than normal LDL. This modified LDL builds plaques even at "normal" cholesterol numbers. This is why statins fail in dialysis patients — the lipoproteins themselves have been poisoned by the uremic environment.
Frontiers CV Medicine 2025 · PMC Uremic Toxin Review 2016 ↗ Read Study
Key insight: This is why a "normal" LDL of 100 in a person with fatty liver and early kidney stress can be as dangerous as an LDL of 300 in a healthy person. The number on your report does not tell you the full story.
The Proof Is in the Name
The Word Hridayam Encoded the Heart's Function 2,000 Years Before William Harvey "Discovered" Circulation
In Sanskrit, naming conventions were documentation. The word Hridayam contains a precise physiological description:
(venous return)
(arterial output)
circulating
William Harvey described blood circulation in 1628 CE. The word Hridayam described it in ~400 BCE.
The proof was always in the name.
Even Slightly Weak Kidneys Double Your Heart Attack Risk. Your Kidney Report Can Show "Normal" — And Still Be Damaging Your Heart.
The Lancet confirmed: impaired kidney function raises cardiovascular risk 2–4× — independently of blood pressure, diabetes, and cholesterol combined.
What makes this alarming: people with CKD are more likely to die from heart disease than from kidney failure itself. Sushruta documented this precisely.
Sushruta Samhita — ~400 BCE
Vrikka Roga (kidney disease) directly causes Hridaya Upadrava (heart complications). No heart treatment is permanent until the kidneys are treated first. Weak kidneys weaken the heart; a weak heart reduces kidney blood supply — a downward spiral.
Charaka Samhita + Sushruta Samhita — Vrikka Roga Upadrava chapters
The Lancet + European Heart Journal — 2013–2025
Impaired kidney function raises cardiovascular risk 2–4× independently of blood pressure, diabetes, and cholesterol. People with CKD are more likely to die from heart disease than kidney failure. Medicine now calls this Cardiorenal Syndrome.
The Lancet 2013 · European Heart Journal 2025 ↗ The Lancet ↗ Eur Heart J
Your LDL Is 90. Your Doctor Is Satisfied. So Why Do You Still Feel Like Something Is Wrong?
You are not imagining it — there is a clinical reason. Statins effectively lower one number in one organ. But heart disease is a three-organ problem. What statins don't cover is where damage continues.
✓ What statins address
- LDL cholesterol production in the liver (one pathway only)
- Modest plaque stabilisation
- Some reduction in cardiac events in pre-dialysis patients
✗ What statins cannot address
- Internal liver lipogenesis — de novo cholesterol manufacturing
- Uremic toxin load from failing kidneys
- Systemic inflammation — hsCRP, IL-6, TNF-alpha
- RAAS activation driving blood pressure overload
- Ama formation — the weaponisation of LDL by uremic toxins
- CoQ10 depletion — statins block this critical heart-energy molecule
"Statins address one pathway. Heart disease is a three-organ problem. What statins don't cover — liver lipogenesis, uremic toxins, inflammation — that gap is where damage continues."
This Has Been Happening Inside Your Body for 10 to 20 Years. Heart Disease Does Not Begin With a Heart Attack.
The heart attack is the last event in a very long story. Here is that story — and when each chapter most likely started in your own body.
Stage 1 · Your 30s
The liver begins quietly accumulating fat
No pain. No symptoms. Perhaps a sluggish feeling after meals. Fatty liver begins silently — often from excess sugar and refined carbs. Ranjaka Pitta loses its ability to regulate Meda Dhatu.
Most people have no idea at this stageStage 2 · Late 30s–40s
The liver starts manufacturing dangerous internal cholesterol
The damaged liver begins producing excess VLDL and small dense LDL through de novo lipogenesis. Your diet is not the source. A standard lipid test shows rising triglycerides and low HDL.
This is where most people first get "high cholesterol" resultsStage 3 · Early–Mid 40s
The kidneys begin struggling under the toxic blood load
Inflammatory blood starts damaging kidney filtration units. eGFR declines slowly. Creatinine creeps up. Most kidney tests still return "normal."
eGFR above 60 looks normal — but Stage 2 CKD is already raising heart riskStage 4 · Mid 40s–50s
Uremic toxins weaponise your cholesterol
Uremic toxins accumulate and chemically modify LDL — making it 3–5× more likely to form plaques. Simultaneously, RAAS activation raises blood pressure and overloads the heart. Ama is now circulating systemically.
Your "normal" LDL is now dangerously modified — but the test still shows one numberStage 5 · 50s–60s
The heart overloads — event risk peaks
The heart has compensated for years. Left ventricular hypertrophy develops. A soft, inflamed plaque ruptures. A clot forms. The heart attack that "came suddenly" had been building for 15–20 years.
The "sudden" heart attack was not sudden — it was the end of a 20-year storyWhen You Heal the Liver and Kidneys — Here Is What the Heart Experiences
This is restoration — the three-organ system working the way it was designed to. Each improvement in liver and kidney function creates measurable downstream cardiac benefit.
of adults worldwide have fatty liver — the most ignored hidden driver of cardiovascular disease (AHA 2024)
higher cardiovascular event risk with mild kidney dysfunction — independent of all standard risk factors (The Lancet 2013)
more atherogenic: what uremic toxins do to LDL at the same level (PMC Uremic Toxin Review 2016)
When the liver heals
- Stops producing dangerous small dense LDL internally
- Restores HDL's protective function and cholesterol transport
- Reduces CRP and IL-6 — the inflammation markers that damage artery walls
- Improves bile production, reducing triglyceride load on the heart
- Reduces epicardial fat driving cardiac inflammation
When the kidneys improve
- Uremic toxins clear — LDL becomes far less atherogenic
- Blood pressure normalises as RAAS activation reduces
- Fluid balance restores — reducing cardiac preload
- Left ventricular hypertrophy begins to regress as cardiac workload falls
- Systemic inflammation declines as the primary toxin source is addressed
Peer-reviewed studies show measurable improvement in cardiac biomarkers within 3–6 months of combined hepatic and renal support. (Frontiers CV Med 2024, Eur Heart J 2025)
The Research Behind Everything on This Page
Five studies. Plain language. No marketing. Every claim on this page links directly to its source journal — click any link to verify.
Fatty liver raises major heart event risk — 5.6 million people, 10-year study
A nationwide study of 5.6 million adults, followed over 10 years, found those with fatty liver had dramatically higher rates of heart attack, stroke, and heart failure — even after removing obesity, diabetes, and blood pressure as risk factors. Cardiovascular disease, not liver disease, was the primary cause of mortality.
Scientific Reports · Nature Publishing Group · February 2025 ↗ Read Full Study
Kidney dysfunction raises heart risk 2–4× independently of cholesterol and blood pressure
The Lancet: even mild kidney decline raises cardiovascular risk 2–4× — over and above your cholesterol or blood pressure. People with CKD are more likely to die from heart disease than kidney failure itself.
The Lancet · 2013 · Reconfirmed European Heart Journal · 2025 ↗ The Lancet ↗ Eur Heart J 2025
The American Heart Association now mandates liver screening for all heart disease patients
In 2024, the AHA issued formal guidelines: fatty liver disease (MASLD) is now an independent cardiovascular risk factor, and all heart patients must be screened for liver health. For the first time in cardiology history, the liver is a mandatory part of heart disease assessment.
Circulation · American Heart Association · 2024 ↗ Read AHA Guidelines
Diet alone cannot fix liver-driven cholesterol — confirmed at the molecular level
Peer-reviewed research confirmed that fatty liver drives cholesterol production through de novo lipogenesis — completely independent of dietary fat. The liver produces dangerous LDL from sugar and carbohydrates. Reducing dietary fat cannot stop this internal manufacturing process.
Frontiers in Cardiovascular Medicine · 2024 ↗ Read Study · NCBI Lipid Metabolism Review ↗ Read Review
Weak kidneys chemically weaponise your cholesterol — even at "normal" numbers
When kidney filtration is impaired, uremic toxins chemically modify LDL — making it 3–5× more likely to form arterial plaques. A "normal" LDL of 100 with early kidney dysfunction can be as dangerous as an LDL of 300 in a healthy person. The number on your report does not tell the full story.
Frontiers in Cardiovascular Medicine · 2025 ↗ Read Study · PMC Uremic Toxins Review ↗ Read Review
Your Annual Heart Checkup Looks at 5 Things. The Three-Organ System Needs 8 More.
This is not about replacing your doctor — it is about going to your next appointment with better questions.
| Test | Monitors | Why it matters for the heart | Organ |
|---|---|---|---|
| Lipid Panel (LDL, HDL, TG) | Circulating cholesterol | Standard — but misses internal liver production and modified LDL | Heart |
| Blood Pressure | Arterial pressure | Standard — but misses the kidney RAAS activation driving it | Heart |
| ALT / AST | Liver enzyme levels | Early marker of liver stress — rises before any symptoms appear | Liver |
| GGT (Gamma-GT) | Liver inflammation | More sensitive than ALT/AST for early fatty liver — strongly predicts cardiovascular events | Liver |
| Serum Creatinine + eGFR | Kidney filtration rate | eGFR below 75 already raises cardiovascular risk — most labs only flag below 60 | Kidney |
| UACR (Urine Albumin) | Earliest kidney damage | The most sensitive early cardio-kidney risk marker — rarely tested outside specialist care | Kidney |
| hsCRP | Systemic inflammation | Predicts cardiac events independently of LDL — better predictor than LDL in the JUPITER trial | All 3 |
| HbA1c | Average blood sugar | Metabolic stress driving de novo lipogenesis in liver and glomerular damage in kidneys | All 3 |
Ask your doctor for these at your next visit — all available at any diagnostic lab in India.
Told Honestly. No Numbers. No Cure Claims.
Rajesh M., 54
Retired engineer, Pune. On statins for 7 years.
"I had been on statins since I was 47. My cardiologist was satisfied every year — LDL under 90, blood pressure controlled. But I was breathless climbing one flight of stairs, tired by noon, and my triglycerides never came down no matter what I ate or stopped eating. My last ultrasound had mentioned 'Grade 1 fatty changes' in the liver. Nobody connected these things for me."
We Did Not Invent a Formula. We Went Back to Charaka — And Then Went to the Journals.
Why Clear Heaart Combo Pack exists
We kept seeing the same pattern: people doing everything right for their heart — diet, exercise, medication — and still deteriorating. The Charaka Samhita cross-referenced with 2024 peer-reviewed research gave a consistent answer: nobody was treating all three organs together. The liver, kidneys and heart were managed in separate silos — without anyone connecting the upstream cause to the downstream damage.
Clear Heaart Combo Pack does not claim to be a cure. It was built to close that gap — the three-organ system standard cardiology does not yet routinely treat as one. Every ingredient was selected for its Ayurvedic text reference AND its peer-reviewed mechanism. Both. Together.
Shreenath Sharma — Ayurvedic Vaidya
BAMS, MD Ayurveda · Formulation reviewed for classical text accuracy and modern herb-drug interaction
"The Koshthanga connection Charaka described is clinically observable every day. Patients with heart disease almost always have concurrent liver or kidney stress — yet these are rarely treated together. This formulation addresses that gap in a way that is classically grounded and research-supported."
The Solution
This Is Exactly Why Clear Heaart Combo Pack Was Built — To Address All Three, Together, The Way Charaka Prescribed It.
We took what the Charaka Samhita documented 2,400 years ago and verified every ingredient against peer-reviewed research. Both together — not one without the other. The science and the tradition speak for themselves.
Stop internal cholesterol production.
Reduce uremic toxin load.
Reduce arterial inflammation.
100-Day Money-Back Guarantee. If you do not feel a meaningful difference in your energy, digestion, and overall wellbeing within 100 days — we refund every rupee. No questions asked.
Honest expectations — what to expect and when
Three Questions. Answered Honestly.
Is Ayurveda as reliable as modern medicine?
Two paths, one destination. What Charaka documented 2,400 years ago, the AHA published in 2024. What Sushruta called Vrikka Roga causing Hridaya Upadrava, modern medicine named Cardiorenal Syndrome in 2004. The difference is vocabulary, not truth. We use both — because neither alone is complete.
Can Clear Heaart Combo Pack replace my heart medication or statins?
No — and we will never say that. Clear Heaart Combo Pack supports the three-organ system that standard cardiology does not yet routinely treat together. It works alongside your existing care. Continue your prescribed medication and consult your doctor before any changes. But also ask about your liver enzymes and kidney filtration markers — those numbers tell a story your lipid panel misses.
How long before I notice something?
Ayurvedic herbs restore function — they do not suppress symptoms. In weeks 1–2 most people notice improved energy and digestion. In months 2–3, liver and kidney markers typically begin improving. The measurable cardiac impact builds from month 4 onwards. A statin lowers one number in 4 weeks — that is suppression. This is something different, and more lasting.
*These statements have not been evaluated by a drug regulatory authority. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your physician before beginning any supplement protocol.